Estradiol modulation of cortical, striatal and raphe nucleus 5-HT1A and 5-HT2A receptors of female hemiparkinsonian monkeys after long-term ovariectomy.
Identifieur interne : 001676 ( Main/Exploration ); précédent : 001675; suivant : 001677Estradiol modulation of cortical, striatal and raphe nucleus 5-HT1A and 5-HT2A receptors of female hemiparkinsonian monkeys after long-term ovariectomy.
Auteurs : Maria Gabriela Sánchez [Canada] ; Erika Estrada-Camarena ; Nancy Bélanger ; Marc Morissette ; Thérèse Di PaoloSource :
- Neuropharmacology [ 1873-7064 ] ; 2011.
English descriptors
- KwdEn :
- Animals, Autoradiography, Cerebral Cortex (drug effects), Cerebral Cortex (metabolism), Corpus Striatum (drug effects), Corpus Striatum (metabolism), Estradiol (pharmacology), Estrogens (pharmacology), Female, Macaca fascicularis, Ovariectomy, Parkinson Disease, Secondary (metabolism), Raphe Nuclei (drug effects), Raphe Nuclei (metabolism), Receptor, Serotonin, 5-HT1A (metabolism), Receptor, Serotonin, 5-HT2A (metabolism).
- MESH :
- chemical , metabolism : Receptor, Serotonin, 5-HT1A, Receptor, Serotonin, 5-HT2A.
- chemical , pharmacology : Estradiol, Estrogens.
- drug effects : Cerebral Cortex, Corpus Striatum, Raphe Nuclei.
- metabolism : Cerebral Cortex, Corpus Striatum, Parkinson Disease, Secondary, Raphe Nuclei.
- Animals, Autoradiography, Female, Macaca fascicularis, Ovariectomy.
Abstract
Depression is common in Parkinson's disease and an imbalance in serotonin neurotransmission could be implicated. Estradiol is reported to modulate brain serotonin systems of rodents and monkeys, but this has not been explored in primate models of Parkinson's disease. Thus, the present study investigated the effect of estradiol on 5-HT(1A) and 5-HT(2A) serotonin receptors in the cortex, striatum and raphe nucleus of long-term ovariectomized hemiparkinsonian monkeys. Seven monkeys were ovariectomized and received a month later a unilateral lesion with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Four years after lesion and ovariectomy, three received a month of treatment with 17β-estradiol and four the vehicle. Autoradiography of [(3)H]8-OH-DPAT specific binding to 5-HT(1A) receptors showed a decrease in the frontal cortex of monkeys treated with 17β-estradiol in both hemispheres of the brain. [(3)H]ketanserin specific binding to 5-HT(2A) receptors was increased in the frontal cortex and the striatum of monkeys treated with 17β-estradiol in both the lesioned and intact sides of the brain. Autoradiography of [(35)S]GTPγS specific binding stimulated with R-(+)-8-OH-DPAT showed a decrease in the percentage of stimulation in the frontal cortex of monkeys treated with 17β-estradiol in both hemispheres of the brain and in the dorsal raphe nucleus. Treatment with 17β-estradiol was initiated a long time after ovariectomy in monkeys to model post menopausal hormonal conditions and showed that serotonin receptors were still responsive in the brain regions investigated. These results support a role for 17β-estradiol on serotonin activity in Parkinson's disease and could be useful for treatment of depression associated with this disease.
DOI: 10.1016/j.neuropharm.2010.11.024
PubMed: 21144854
Affiliations:
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Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Molecular Endocrinology and Genomic Research Center, Centre de recherche du CHUQ (CHUL), Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Estrada Camarena, Erika" sort="Estrada Camarena, Erika" uniqKey="Estrada Camarena E" first="Erika" last="Estrada-Camarena">Erika Estrada-Camarena</name></author><author><name sortKey="Belanger, Nancy" sort="Belanger, Nancy" uniqKey="Belanger N" first="Nancy" last="Bélanger">Nancy Bélanger</name></author><author><name sortKey="Morissette, Marc" sort="Morissette, Marc" uniqKey="Morissette M" first="Marc" last="Morissette">Marc Morissette</name></author><author><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name></author></analytic><series><title level="j">Neuropharmacology</title><idno type="eISSN">1873-7064</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Autoradiography</term><term>Cerebral Cortex (drug effects)</term><term>Cerebral Cortex (metabolism)</term><term>Corpus Striatum (drug effects)</term><term>Corpus Striatum (metabolism)</term><term>Estradiol (pharmacology)</term><term>Estrogens (pharmacology)</term><term>Female</term><term>Macaca fascicularis</term><term>Ovariectomy</term><term>Parkinson Disease, Secondary (metabolism)</term><term>Raphe Nuclei (drug effects)</term><term>Raphe Nuclei (metabolism)</term><term>Receptor, Serotonin, 5-HT1A (metabolism)</term><term>Receptor, Serotonin, 5-HT2A (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptor, Serotonin, 5-HT1A</term><term>Receptor, Serotonin, 5-HT2A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Estradiol</term><term>Estrogens</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cerebral Cortex</term><term>Corpus Striatum</term><term>Raphe Nuclei</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cerebral Cortex</term><term>Corpus Striatum</term><term>Parkinson Disease, Secondary</term><term>Raphe Nuclei</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Autoradiography</term><term>Female</term><term>Macaca fascicularis</term><term>Ovariectomy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Depression is common in Parkinson's disease and an imbalance in serotonin neurotransmission could be implicated. Estradiol is reported to modulate brain serotonin systems of rodents and monkeys, but this has not been explored in primate models of Parkinson's disease. Thus, the present study investigated the effect of estradiol on 5-HT(1A) and 5-HT(2A) serotonin receptors in the cortex, striatum and raphe nucleus of long-term ovariectomized hemiparkinsonian monkeys. Seven monkeys were ovariectomized and received a month later a unilateral lesion with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Four years after lesion and ovariectomy, three received a month of treatment with 17β-estradiol and four the vehicle. Autoradiography of [(3)H]8-OH-DPAT specific binding to 5-HT(1A) receptors showed a decrease in the frontal cortex of monkeys treated with 17β-estradiol in both hemispheres of the brain. [(3)H]ketanserin specific binding to 5-HT(2A) receptors was increased in the frontal cortex and the striatum of monkeys treated with 17β-estradiol in both the lesioned and intact sides of the brain. Autoradiography of [(35)S]GTPγS specific binding stimulated with R-(+)-8-OH-DPAT showed a decrease in the percentage of stimulation in the frontal cortex of monkeys treated with 17β-estradiol in both hemispheres of the brain and in the dorsal raphe nucleus. Treatment with 17β-estradiol was initiated a long time after ovariectomy in monkeys to model post menopausal hormonal conditions and showed that serotonin receptors were still responsive in the brain regions investigated. These results support a role for 17β-estradiol on serotonin activity in Parkinson's disease and could be useful for treatment of depression associated with this disease.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Belanger, Nancy" sort="Belanger, Nancy" uniqKey="Belanger N" first="Nancy" last="Bélanger">Nancy Bélanger</name><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name><name sortKey="Estrada Camarena, Erika" sort="Estrada Camarena, Erika" uniqKey="Estrada Camarena E" first="Erika" last="Estrada-Camarena">Erika Estrada-Camarena</name><name sortKey="Morissette, Marc" sort="Morissette, Marc" uniqKey="Morissette M" first="Marc" last="Morissette">Marc Morissette</name></noCountry><country name="Canada"><noRegion><name sortKey="Sanchez, Maria Gabriela" sort="Sanchez, Maria Gabriela" uniqKey="Sanchez M" first="Maria Gabriela" last="Sánchez">Maria Gabriela Sánchez</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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